| 名稱 | Recombinant Human β-NGF |
| 型號 | |
| 更新時間 | 2022-09-24 |
| 特點 | β-NGF神經營養因子結構與BDNF,NT-3 NT-4相同。β-NGF強有力的神經營養因子,通過其受體β-NGFR信號,并在開發和保護中扮演著關鍵角色的感覺和交感神經系統。β-NGF還可以作為B淋巴細胞的生長和分化因素型和增強B細胞生存。使用所有無動物生產試劑。} |
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- 詳細(xi)內容
一.產品名稱：Recombinant Human β-NGF/重組蛋白β-NGF
二.Catalog Number:AF-450-01
三.Synonyms:NGF-β
四.Description:
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (238 total amino acid residues). The three disulfide bonds are required for biological activity. Manufactured using all non-animal reagents.
五.AA Sequence:
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVR
六.Source:E.coli
七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
八.Biological Activity:
Assay 1:Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Assay 2:Determined by its ability to stimulate chick E9 DRG neurite outgrowth. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
九.Cross Reactivity:Chicken, Hamster, Mouse, Rat, Human
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電話/傳真：13366128764
手機：15311648455
地址：北京市海淀區廂黃旗2號樓1層4-179室