Recombinant Murine M-CSF-北京科瑞美科技有限公司

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名稱	Recombinant Murine M-CSF
型號
更新時間	2022-09-24
特點	M-CSF是一個有效的造血因子由多種細胞包括淋巴細胞、單核細胞、成纖維細胞、內皮細胞、成肌細胞和成骨細胞。M-CSF臨床上用于治療感染,惡性腫瘤和動脈粥樣硬化。它促進骨髓移植后造血恢復。重組小鼠M-CSF是36.4 kDa homodimeric蛋白質包含兩個156氨基酸多肽子單元。使用所有無動物生產試劑。}

詳細內容

一.產品名稱：Recombinant Murine M-CSF/Peprotech M-CSF

二.Catalog Number:AF-315-02

三.Synonyms:Macrophage Colony Stimulating Factor, CSF-1, MGI-IM

四.Description:

M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4 kDa homodimeric protein containing two 156 amino acid polypeptide subunits. Manufactured using all non-animal reagents.

五.AA Sequence:

MKEVSEHCSH MIGNGHLKVL LIDSQMET SCQIAFEFVD QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

Determined by its ability to stimulate the proliferation of murine M-NFS-60 cells. The expected ED₅₀ is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥1 x 10⁶ units/mg.

九.Cross Reactivity:Mouse, Rat