| 名稱 | Recombinant Human TNF-α |
| 型號 | |
| 更新時間 | 2022-09-24 |
| 特點 | TNF-α是pleiotrophic促炎細胞因子分泌的多種細胞包括脂肪細胞,激活單核細胞、巨噬細胞、B細胞、T細胞和成纖維細胞。它屬于TNF家族的配體和信號通過兩個受體,TNFR1 TNFR2。TNF-α是各種腫瘤細胞和細胞毒性是一個重要的中介因素對細菌感染的免疫反應。TNF-α也扮演了重要的角色在感染性休克的感應,自動免疫疾病、風濕性關節炎、炎癥和糖尿病。} |
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- 詳細內容
一.產品名稱：Recombinant Human TNF-α/Peprotech TNF-α
二.Catalog Number:AF-300-01A
三.Synonyms:
Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin
四.Description:
TNF-α is a pleiotrophic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein. Manufactured using all non-animal reagents.
五.AA Sequence:
VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL
六.Source:E.coli
七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
八.Biological Activity:
The ED50as determined by the cytolysis of murine L929 cells in the presence of Actinomyocin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
九.Cross Reactivity:Cow, Monkey, Mouse, Rat, Sheep, Human, Dog, Pig, N/A, Human + Virus
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電話/傳真：13366128764
手機：15311648455
地址：北京市海淀區廂黃旗2號樓1層4-179室